By Jan Lotvall
content material: Similarities and changes within the pathophysiology of bronchial asthma and COPD / Christian Virchow --
Glucocorticoids : pharmacology and mechanisms / Peter Barnes --
Inhaled corticosteroids? scientific results in bronchial asthma and COPD / Paul O'Byrne --
LABAS : pharmacology, mechanisms and interplay with anti inflammatory remedies / Gary Anderson --
lengthy and ultra-long performing beta-2-agonists / Mario Cazzola --
the security of long-acting beta agonists and the advance of blend remedies for bronchial asthma and protracted obstructive pulmonary ailment / Eugene Bleecker --
Inhaled blend remedy with glucocorticoids and long-acting beta-2-agonists in bronchial asthma and COPD, present and destiny views / Jan Lotvall --
Novel anti inflammatory remedies for bronchial asthma and COPD / Ian Adcock --
Novel biologicals by myself and together in bronchial asthma and allergic reaction / William Busse --
Anti-infective remedies in bronchial asthma and COPD / Jonathan D.R. Macintyre & Sebastian L. Johnston --
lengthy performing muscarinic antagonists in bronchial asthma and COPD / Denis O'Donnell --
Phosphodiesterase inhibitors in obstructive lung disorder / Jan Lotvall --
organic remedies in improvement for COPD / Riccardo Polosa --
Triple therapy?, within the administration of power obstructive lung ailment (COPD). the worth of mix remedy with inhaled steroid, lengthy performing anticholinergicbronchodilator and lengthy appearing beta 2 agonist bronchodilator in COPD / Ronald Dahl.
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Additional resources for Advances in combination therapy for asthma and COPD
Steroids 2007;72:221–30. 33. Ito K, Yamamura S, Essilﬁe-Quaye S, et al. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-B suppression. J Exp Med 2006;203:7–13. 34. Anderson P, Phillips K, Stoecklin G, Kedersha N. Post-transcriptional regulation of proinﬂammatory proteins. J Leukoc Biol 2004;76:42–7. 35. Dean JL, Sully G, Clark AR, Saklatvala J. The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.
Am J Respir Crit Care Med 1999;160:1635–9. Culpitt SV, Rogers DF, Shah P, et al. Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;167:24–31. Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 2001;15:1100–2. Ito K, Tomita T, Barnes PJ, Adcock IM.
38. Bergmann MW, Staples KJ, Smith SJ, Barnes PJ, Newton R. Glucocorticoid inhibition of GMCSF from T cells is independent of control by NF-B and CLE0. Am J Respir Cell Mol Biol 2004;30:555–63. 39. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006;27:413–26. 40. Barnes PJ. Cortoicosteroid effects on cell signalling. Eur Respir J 2006;27(2):413–26. 41. Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J Endocrinol 2003;178:5–12.
Advances in combination therapy for asthma and COPD by Jan Lotvall