Read e-book online Aging is a group-selected adaptation: theory, evidence, and PDF

By Joshua Mitteldorf

ISBN-10: 1315354039

ISBN-13: 9781315354033

ISBN-10: 1498715281

ISBN-13: 9781498715287

ISBN-10: 1498715303

ISBN-13: 9781498715300

Because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary idea, specifically within the region of genetics. simultaneously, a technological know-how of multilevel choice has chanced on its position within the evolutionary literature. the writer means that facts warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic idea of senescence, wherein getting older has Read more...

summary: because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary conception, specially within the region of genetics. simultaneously, a technological know-how of multilevel choice has came upon its position within the evolutionary literature. the writer means that proof warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic idea of senescence, wherein getting older has been affirmatively chosen since it degrees the dying cost over the years, assisting to stabilize inhabitants dynamics and stop extinctions

Show description

Read Online or Download Aging is a group-selected adaptation: theory, evidence, and medical implications PDF

Best geriatrics books

New PDF release: Ethics, Law, and Aging Review, Volume 9: Assuring Safety in

This quantity explores the concept that of protection as utilized within the long-term care context. Chapters study the best way the search for protection may match both synergistically or adversely upon different necessary social objectives. one of the projects thought of are selling the decision-making autonomy of patients/clients and their surrogates, bettering the standard of care and caliber of existence to be had to long-term care citizens, and offering reasonable reimbursement for injured sufferers whilst severe damage happens.

Jeffrey L Cummings, Serge Gauthier's Alzheimer's disease and related disorders annual. / 2001 PDF

The editors and participants handle modern subject matters during this quarter via comprehensively referenced chapters, in accordance with scientific event and medical facts designed to stimulate dialogue of the place present therapy is heading. content material: e-book conceal; name; Contents; members; Preface; Amyloid processing in Alzheimer's sickness mind; Cerebral amyloid (congophilic) angiopathy; medical use of neuroimaging within the evaluate of dementia; scientific trials in light cognitive impairment; Muscarinic agonists in Alzheimer's ailment; melancholy in dementia; melancholy in neurodegenerative issues and comparable stipulations; Use of antipsychotic medicines in dementia; Assessing competency in Alzheimer's disorder: therapy consent capability and monetary means; administration of past due level dementia; Index.

Ethical Considerations and Challenges in Geriatrics by Angela Georgia Catic PDF

This e-book is designed to offer an outline of universal geriatrics moral concerns that come up in the course of sufferer care and study actions. each one bankruptcy incorporates a case instance and sensible studying pearls which are worthy in daily sufferer care. insurance contains a short assessment of geriatric epidemiology, highlighting the excessive charges of dementia, use of surrogate judgements makers on the end-of-life, relocation from domestic to long term care amenities, and coffee healthiness literacy within the geriatrics inhabitants.

Sara C. Zapico's Mechanisms linking aging, diseases, and biological age PDF

This publication makes a speciality of 4 of the hallmarks of getting older: aspartic acid racemization, complicated glycation finish items, telomere shortening and mitochondrial mutations; describing their function in getting older and illnesses; and their software to age-at-death estimation in forensic sciences in larger intensity, showing the interconnecting pathways between those methods.

Extra info for Aging is a group-selected adaptation: theory, evidence, and medical implications

Example text

Elegans worm to die early when there is danger of overpopulation is a powerful hint. The purpose of the CR adaptation is to adjust lifespan to complement the death rate from starvation. When starvation deaths are high, aging deaths are low and vice versa. In starving animals, it is also true that stress resistance is enhanced. In fact, the genes that signal life extension have very generally been found to be the same genes that fortify stress resistance. The mechanisms are one and the same. Animals respond to caloric restriction with better resistance to disease [50], enhanced agility and speed [51], and quicker, more reliable neuronal responses [52].

Similar to the dauer, the CR response is a decision to forgo immediate reproduction, to lengthen lifespan, to bet on survival and an opportunity to reproduce later. * In addition to the extremes of dauering, the worms also have a CR adaptation, and they decide how long to live and how rapidly to reproduce based on chemical signals they pick up about how much food is around and how many other worms are competing for that food. All this is done with 302 nerve cells. We know that the nerves are making the decision, rather than some purely chemical signaling, through elegant experiments at Ruvkun’s Harvard lab [48] and Guarante’s lab at MIT [49].

To see this effect, methionine intake must be restricted at a level lower than any natural protein source would permit, so the experiment is done with synthetic chows, containing refined and re-mixed amino acids. Timing of food intake is also important in a way that escaped the notice of CR researchers for many years. Intermittent fasting can lead to substantial life extension, even if total caloric intake is unaffected. Mice that are fed every other day tend to double-up when food is available, so that their total caloric intake is barely diminished from ad libitum fed mice.

Download PDF sample

Aging is a group-selected adaptation: theory, evidence, and medical implications by Joshua Mitteldorf


by Daniel
4.3

Rated 4.93 of 5 – based on 6 votes